1/ What is Hydrosol 40?
Hydrosol 40 (Macrogolglycerol Hydroxystearate, Polyoxyl 40 Hydrogenated Castor Oil) is a nonionic solubilizer, emulsifier, and primary surfactant, recognized as an industry standard.
2/ Key Advantages:
Superior solubilization for poorly soluble APIs.
Enhances bioavailability by forming nanosized micelles (10–25 nm).
Odorless, nearly tasteless, chemically stable, and compatible with various solvents.
Can be sterilized at 120 °C, largely insensitive to water hardness.
Advanced with WHO-GMP, ISO, GSP, GSP Certification
3/ Applications:
Hydrosol 40 is widely used in lipid-based drug delivery systems (SEDDS/SMEDDS). Typical applications include:
Softgel capsules – 400 mg/dose.
Oral solutions – 0.5–45%.
Ophthalmic formulations – 0.5% w/w.
Creams – 1% w/w.
Tablets
4/ Commercial Products using Polyoxyl 40 Hydrogenated Castor Oil:
With its outstanding performance, Hydrosol 40 is a proven excipient to improve formulation stability and enhance drug bioavailability.
This post is prepared by Jorie
